Soon after the first reports of the association of erythema multiforme and "lichen pimple" published in Urbach, Anderson already called the herpes simplex virus a "time bomb" in relation to this. The 70 years that have passed since then have not only not changed the situation, but have given it a special urgency. If at the initial stages of studying this process the main issue was the search for causal factors, today there are other tasks related to the study of pathogenesis and the selection of therapy
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