Book description

The process of cutaneous leishmaniasis is characterized by a sluggish, long­term course due to weak local anti-infective immunity. Therefore, we tried to stimulate local immunity using the official gramicidin paste. To assess the contribution o f the antibiotic action ofgramicidin S, monomycin ointment was used in one o f the control groups as the most effective anti-leishmania drug among the antibiotic agents used to treat cutaneous leishmaniasis.
The significantly more effective therapeutic effect o f gramicidin in the main group compared to monomycin indicates that the effect o f gramicidin is determined not only by its antibiotic activity. There is enough reason to assume that gramicidin S has a local immunoslimulating effect, which, in combination with the antibiotic effect, gives a very good therapeutic effect for cutaneous leishmaniasis.